Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling
Pathological cardiac remodeling predisposes individuals to developing heart failure.Here, we investigated two co-regulated long non-coding RNAs (lncRNAs), termed Gadlor1 and Gadlor2, which are upregulated in failing hearts of Equestrian Riding Gloves patients and mice.Cardiac overexpression of Gadlor1 and Gadlor2 aggravated myocardial dysfunction a